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Good News: Covid-19 patients recover at a faster rate after getting experimental drug remdesivir

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Information reaching acostik.com is that a hospital in Chicago treating covid 19 patients with an experimental drug called remdesivir has witnessed a massive recovery with nearly all patients being discharged in less than a week.

Remdesivir was one of the first medicines discovered as having the potential to combat the SARS CoV-2,the novel coronavirus that causes covid-19.It is an antiviral medication; a nucleotide analog, specifically an adenosine analogue, which inserts into viral RNA chains, causing their premature termination.

The covid-19 patients taking part in the clinical trial of the drug had all the fever and respiratory symptoms before the drugs were administered to them.According to statnews, all the patients were treated with daily infusions of remdesivir .

“The best news is that most of our patients have already been discharged, which is great. We’ve only had two patients perish,” said Kathleen Mullane, the University of Chicago infectious disease specialist overseeing the remdesivir studies for the hospital .

“It’s always hard,” she said, because the severe trial doesn’t include a placebo group for comparison. “But certainly when we start the drug, we see fever curves falling,” she said. “Fever is now not a requirement for people to go on trial, we do see when patients do come in with high fevers, they do reduce quite quickly. We have seen people come off ventilators a day after starting therapy. So, in that realm, overall our patients have done very well.”

She concluded by saying that “Most of our patients are severe and most of them are leaving at six days, so that tells us duration of therapy doesn’t have to be 10 days. We have very few that went out to 10 days, maybe three,”.

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Just In : Actor Eddie Nartey Has Lost his Wife

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Ghanaian Actor and Movie Producer/Director Eddie Nartey, has lost his beautiful wife Vida Danso.
The actor shared the news in an Instagram post a couple of hours ago.
“I don’t know what to say, I don’t know what to feel. I’m just in constant pain. Rest well my Habibi. God knows Best. I pray for strength!” he wrote.

See post below

Actor Eddie Nartey and Vida Danso tied the knot in a private ceremony on 22nd-September.2018

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What is Clubhouse All About?

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Few months ago Twitter made news for rolling out a voice tweet feature that allowed users to record and post messages. But fortunately for its users,another fast rising social network Clubhouse has been on the trend and also seeking to have the last word in the world of voice-driven social media.

Users around the world are of the view that Clubhouse can become prodigious overnight.It is for this reason we write about what Clubhouse is all about.

What is Clubhouse?

Clubhouse is a new type of network based on voice. When you open the app you can see “rooms” full of people talking—all open so you can hop in and out, exploring different conversations. You enter each room as an audience member, but if you want to talk you just raise your hand, and the speakers can choose to invite you up. Or you can create a room of your own. It’s a place to meet with friends and with new people around the world—to tell stories, ask questions, debate, learn, and have impromptu conversations on thousands of different topics.

So its however,more like a social media platform that allows you to listen in to experts talk on various subjects in real time (and often get to ask questions of them too). Most are structured as a live podcast with Q&A. But like a podcast or Instagram account, anyone can jump on and host a conversation.It’s still in beta, which means only for iPhone users at this point.Why?..This is because features to handle large amount of people are yet to be built.Therefore the only means to ensure that the app functions well is to limit the amount of users who can join every week by virtual invites only.Its also important to note that Clubhouse is voice only so you don’t have to worry about putting on makeup before you join .You also have no reason to worry about where you are, and what you are wearing,all you need to do is to just ‘Talk”.

Another thing you need to know about Clubhouse is that, Instead of typing something and hitting Send, you’re engaged in a back-and-forth dialogue with others.Something i believe will give us the opportunity to build more empathy and robust connections with people.

One of the main ways Clubhouse has been able to make a splash quickly is by getting A- listers in myriad fields to try it. Oprah is perhaps the most famous person to have been seen on Clubhouse. Movie stars like Kevin Hart, Chris Rock, and Jared Leto have also been spotted on it, CNBC reported.

Unlike most social media apps where you can get caught up on the day’s news after the fact, Clubhouse is one where you’ve got to be there to avoid missing out. None of the conversations are recorded, and transcripts are not made available after the fact.

“It’s all ephemeral,” Clubhouse member Meltem Demirors told the Wall Street Journal. “It creates this cool urgency.”

This both encourages people to spend time on the app, and also makes time spent on Clubhouse feel more like a face-to-face conversation offline.

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What’s In the COVID-19 Vaccines?

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Now that there are authorized and recommended COVID-19 vaccines in the United States and many other countries,its imperative that we gain full cognizance about these vaccines. Why ?……As the first doses of COVID-19 vaccines were administered across the various developed countries, a few reports of allergic reactions to Pfizer- BioNTech’s vaccine have raised some concerns for those who are prone to allergic reactions.

Despite these concerns, experts say the risk of experiencing an allergic reaction in response to the authorized vaccines is still low when taking into account the ingredients present in both.Before we get to the nitty gritties of these vaccines ,Lets look at how vaccines work.

HOW VACCINES WORK

Germs are all around us, both in our environment and in our bodies. When a person is susceptible and they encounter a harmful organism, it can lead to disease and death.

The body has many ways of defending itself against pathogens (disease-causing organisms). Skin, mucus, and cilia (microscopic hairs that move debris away from the lungs) all work as physical barriers to prevent pathogens from entering the body in the first place. When a pathogen does infect the body, our body’s defences, called the immune system, are triggered and the pathogen is attacked and destroyed.

The body’s natural response

A pathogen is a bacterium, virus, parasite or fungus that can cause disease within the body. Each pathogen is made up of several sub-parts, usually unique to that specific pathogen and the disease it causes. The subpart of a pathogen that causes the formation of antibodies is called an antigen. The antibodies produced in response to the pathogen’s antigen are an important part of the immune system. You can consider antibodies as the soldiers in your body’s defense system. Each antibody, or soldier, in our system is trained to recognize one specific antigen. We have thousands of different antibodies in our bodies. When the human body is exposed to an antigen for the first time, it takes time for the immune system to respond and produce antibodies specific to that antigen. In the meantime, the person is susceptible to becoming ill. 

Once the antigen-specific antibodies are produced, they work with the rest of the immune system to destroy the pathogen and stop the disease. Antibodies to one pathogen generally don’t protect against another pathogen except when two pathogens are very similar to each other, like cousins. Once the body produces antibodies in its primary response to an antigen, it also creates antibody-producing memory cells, which remain alive even after the pathogen is defeated by the antibodies. If the body is exposed to the same pathogen more than once, the antibody response is much faster and more effective than the first time around because the memory cells are at the ready to pump out antibodies against that antigen.This means that if the person is exposed to the dangerous pathogen in the future, their immune system will be able to respond immediately, protecting against disease.

How vaccines help

Vaccines contain weakened or inactive parts of a particular organism (antigen) that triggers an immune response within the body. Newer vaccines contain the blueprint for producing antigens rather than the antigen itself. Regardless of whether the vaccine is made up of the antigen itself or the blueprint so that the body will produce the antigen, this weakened version will not cause the disease in the person receiving the vaccine, but it will prompt their immune system to respond much as it would have on its first reaction to the actual pathogen.

Some vaccines require multiple doses, given weeks or months apart. This is sometimes needed to allow for the production of long-lived antibodies and development of memory cells. In this way, the body is trained to fight the specific disease-causing organism, building up memory of the pathogen so as to rapidly fight it if and when exposed in the future.

Herd immunity

When someone is vaccinated, they are very likely to be protected against the targeted disease. But not everyone can be vaccinated. People with underlying health conditions that weaken their immune systems (such as cancer or HIV) or who have severe allergies to some vaccine components may not be able to get vaccinated with certain vaccines. These people can still be protected if they live in and amongst others who are vaccinated. When a lot of people in a community are vaccinated the pathogen has a hard time circulating because most of the people it encounters are immune. So the more that others are vaccinated, the less likely people who are unable to be protected by vaccines are at risk of even being exposed to the harmful pathogens. This is called herd immunity.

This is especially important for those people who not only can’t be vaccinated but may be more susceptible to the diseases we vaccinate against. No single vaccine provides 100% protection, and herd immunity does not provide full protection to those who cannot safely be vaccinated. But with herd immunity, these people will have substantial protection, thanks to those around them being vaccinated.

Vaccinating not only protects yourself, but also protects those in the community who are unable to be vaccinated. If you are able to, get vaccinated.

Here’s what we know about the Pfizer and Moderna vaccine ingredients and their role in allergic reactions.

What’s in the Vaccine?

The vaccine primarily contains salts and stabilizers in the forms of sugars and lipids, which don’t cause allergic reactions. Pfizer-BioNTech and Moderna’s COVID-19 vaccines are both mRNA vaccines, which use a copy of a natural chemical called mRNA to provoke the body’s immune response. When the immune response is activated, it protects the body from acquiring an infection. “The RNA is packaged in a similar manner in both vaccines, which requires the use of polyethylene glycol, the chemical suspected to induce allergic reactions in a few patients who had an allergic reaction to the Pfizer vaccine,” Sanjeev Jain, MD, PhD, board-certified allergist and immunologist at Columbia Allergy based on the West Coast, tells very well. 

Pfizer-BioNTech’s vaccine contains:

  • A nucleoside-modified messenger RNA (modRNA) encoding the viral spike glycoprotein of SARS-CoV-2
  • Lipids, or fatty substances, including: (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), 2-[(polyethylene glycol)-2000]-N, N-ditetradecylacetamide, 1,2-distearoyl-snglycero-3-phosphocholine, and cholesterol
  • Potassium chloride
  • Monobasic potassium phosphate
  • Sodium chloride (salt)
  • Dibasic sodium phosphate dihydrate 
  • Sucrose (sugar)

The Moderna vaccine contains similar ingredients such as:

  • Messenger ribonucleic acid (mRNA)
  • Lipids, or fatty substances, including: SM(sphyngomyelin)-102, Polyethylene glycol [PEG] 2000 dimyristoyl glycerol [DMG], 1,2-distearoyl-sn-glycero-3-phosphocholine [DSPC], and cholesterol
  • Tromethamine
  • Tromethamine hydrochloride
  • Acetic acid
  • Sodium acetate
  • Sucrose (sugar)

Both vaccines are similar when it comes to ingredients. “The primary difference between the two is that the packaging of the RNA in the Moderna vaccine allows for storage in a regular freezer, compared to ultra-cold freezers required for the storage of the Pfizer vaccine,” Jain says.

Although allergic reactions to the vaccines are possible, Jain says the risk of a reaction to the current COVID-19 vaccines is fairly low. “Most allergic reactions can be attributed to the preservatives or the vial stoppers that are made with latex,” he says. “The vaccine does not contain any of these ingredients.”

Allergic Reactions

There is some concern that vaccine can cause anaphylaxis, a severe and potentially life-threatening allergic reaction. According to Jain and Lakiea Wright, MD, board-certified allergist and immunologist at Brigham and Women’s Hospital in Massachusetts, the COVID-19 vaccines are unlikely to trigger anaphylaxis.

“Anaphylaxis to vaccines is extremely rare,” Wright tells very well. “There is a vaccine-adverse reporting system in the U.S. and although there is variation among different vaccines, on average, the incidence of anaphylaxis after vaccination is approximately 1.3 cases per one million.”

Although it is rare, other allergic reactions can still occur which can be mild to life-threatening. According to the Centers for Disease Control and Prevention (CDC), people should receive the vaccination in a facility where anaphylaxis can be treated.5

While the risk of allergic reactions to the COVID-19 vaccine is low, there is a possibility that a person could react differently. “Any time you take a medication, your body can perceive the medication as foreign, as a threat, and your immune system can mount a response which triggers your allergy cells to fire off,” Wright says. 

Wright stresses that reports of allergic reactions to the Pfizer and Moderna COVID-19 vaccines do not mean that people with all types of allergies shouldn’t get the vaccine. A person’s eligibility for the vaccine depends on their specific allergy history. 

Managing Allergic Reactions

If you decide to get the COVID-19 vaccine, observe for any symptoms or allergic reactions.Jain says a number of symptoms can all indicate a systemic reaction to the vaccine, including:

  • A tickle or clearing of the throat
  • Postnasal drainage
  • Sneezing
  • Coughing
  • Wheezing
  • Tight chest or shortness of breath
  • Abdominal cramping
  • Hives
  • Itching
  • Difficulty swallowing

According to Wright, there are ways to treat allergic reactions, like antihistamines. “In some cases, it may be appropriate to treat with steroids,” he adds. “For a severe allergic reaction, for example, anaphylaxis, the primary treatment is epinephrine.”

Plan Accordingly

If you are planning to take the COVID-19 vaccine, Wright recommends discussing your allergies with your healthcare provider. “If you have any concerns about past allergic reactions and risk for vaccination, make sure you discuss this in detail with your healthcare provider,” Wright says.

If you experience symptoms away from the vaccination shot site, Jain states that you might be experiencing a systemic reaction. “It is a good idea to do a body inventory prior to your injection; make a mental note of any active allergy symptoms for the day,” Jain says. “This will best help the medical staff in determining any change in condition after the shot.”

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